Fibroblast

Fibroblasts are cells in the dermis responsible for secreting elastin and collagen fibres as well as glycosaminoglycans, which form the supportive framework for the skin. They are located within the fibrous matrix and remain connected to the network of fibres they produce. The number of fibroblasts diminishes with age. They also become less productive, resulting in fewer macromolecules in the intercellular matrix. The supportive tissue thus becomes less dense and has a tendency to sag.